Carl-Fredrik Mandenius, Mats Bjorkman Biomechatronic Design in Biotechnology A Methodology for Development of Biotechnological Products 2011

The purpose of this book is to provide the reader with an introduction to systematic design principles and methodology when applied to biotechnology products. Certainly, none of these fields is new on the block – it is the combination of them that brings about a novel approach in this book. The theory of systematic design has almost entirely been devoted to mechanics and electronics, and the biotechnology field has had much of its roots in white biology and in (bio)chemical engineering.
Thus, we are dealing with a subject that lies on the border between biological technology and mechanical and electric engineering. The aim is to integrate important aspects of biological technology with mechanical and electric engineering. In writing a book of this type, there are two major ways of organizing the material, either from the perspective of mechanical design engineering or from the perspective of biotechnology.We have chosen the first for the simple reason that we have used mechatronics methodology from mechanical design engineering as a basis and applied it to biotechnology.
When doing so, we have adapted the methodology to what we call a biomechatronics approach. We presume the book will have mainly two categories of readers, those with a background in biotechnology and related areas and those with a background in mechanics and electronics.We have tried to keep most of the text on a level where both categories of readers would be able to understand the subject.
When this has not been possible, due to space constraints, we have instead provided rather detailed lists of reference literature. We realize that a great deal of the biotechnical details in the application
cases in Chapters 5–13 are probably rather difficult to understand for a person with a background in mechanics and/or electronics. You would need a thorough knowledge of biotechnology in order to comprehend everything in these chapters. However, the main ideas of how to utilize and work with the presented biomechatronic design methodology are possible to understand when reading these chapters. It is not necessary to understand all the biotechnological details in order to have great benefit from these chapters.
We have provided in the book nine application cases from a rather diverse collection of iotechnology products, such as biosensors, analytical instrumentations, production equipment for cell culturing, and protein purification. Some of the products could be characterized more as systems products rather than discrete physical products, for example, PAT-based quality systems.
Readers with their own practical experiences could select from these application cases those relevant to their area of practice. Still, it is necessary to first grasp the general methodology approach and tools, especially explained in Chapter 4 and related to fundamental design theory in Chapter 2, before
starting reading specific application cases. The readers who wish to have a complete overview should of course go through most of the chapters.
We take a great pleasure in expressing thanks to our colleagues Dr. Micael Derel€ov and Dr. Jonas Detterfelt for contributing many valuable ideas and suggestions, in particular, to the initial studies of the subject of the book. Valuable contributions on inquiries and interviews with developers and
companies were made by Maria Uhr and Annika Perhammar. We also thank our academic colleagues in engineering, medicine, and biophysics: Drs. Katrin Zeilinger, J€org Gerlach, Bo Liedberg, Danny van Noort, and Ingemar Lundstr€om. We are also grateful to many biotechnology companies and their personnel who have shared their experiences and endeavors in the development of  biomechatronic products. In particular, we would like to mention Drs. Stefan L€ofa s, Ulf J€onsson, at Biacore; LasseM€ortsell at Belach AB; Stellan Lindberg at Hemocue AB; Stefan Nilsson and Johan Ryd en at Noster AB; Dario Kriz at European Institute of Science AB; and colleagues at Cellartis AB. We owe gratitude to Abbott, Agilent, Affymetrix, Biodot, Charite´ Universita¨tsmedizin Berlin, GE Healthcare, Hemocue, Johnson & Johnson, Kibion, KronLab Chromatography, LifeSpan, Roche Diagnostics, Q-Sense and Mr. Anders Sandelin for providing us figures and pictures.
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