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The book “Mechanosensitivity in Cells and Tissues: Mechanical Stretch and
Cytokines” edited by Andre Kamkin and Irina Kiseleva impressively demonstrates the diversity of cellular effects of cytokines depending on mechanical stimuli. Clinical and fundamental investigation of biological effects of cytokines in regulation of functioning of cells, tissues and organs is a relatively new, interesting and fast growing field, which draws a lot of attention recently. A proposed link between cytokines, their production and mechanisms of action, and their impact on effects of cellular and tissue stretch given a new momentum to this field. The role of cytokines as regulators of stretch related mechanisms is of special importance since mechanosensitivity plays an important role in a wide variety of biological processes. It is known that cytokines can be marked out as a new separate regulatory system which, along with nervous and endocrine systems, helps to maintain homeostasis, and these three systems are tightly interconnected and interdependent. Presently two major approaches to investigation of cytokines and mechanosensitivity exist. The first one focuses on the effects of interplay of mechanical stimulation of tissue or cells and cytokine production. The second approach investigates the influence of cytokines application on mechanosensitivity and mechanotransduction. This Volume is devoted to those two issues. To my knowledge Andre Kamkin and Irina Kiseleva present the first book on this topic, which consists of a collection of publications, written by leading scientists in this field, which guaranties that this Volume will remain of great interest to readers for a long period of time. Present book is devoted to discussion of the latest findings in the filled of cytokines and mechanical stretch of different tissues research. It is evident that the data, available on this topic is scarce, and this Volume is especially valuable, since its 10 Chapters provide a complete description of the modern vision of the field, which is rapidly developing. Volume begins with an overview of cytokines, addressed to those readers, who would like to get acquainted with this topic. In following Chapters authors summarize the recent findings about the cellular and molecular effect of mechanical stretch, which induce cytokine production in cardiomyocytes, fibroblasts, vascular smooth muscle cells, endothelial cells, lung and chondrocytes. Following description of mechanosensitive proinflammatory gene expression is of special interest.
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